{"id":1919,"date":"2024-03-07T23:43:23","date_gmt":"2024-03-07T22:43:23","guid":{"rendered":"https:\/\/dbis.ibp.cz\/?page_id=1919"},"modified":"2025-11-14T01:23:30","modified_gmt":"2025-11-14T00:23:30","slug":"thrombolysis-in-relation-to-ischemic-stroke","status":"publish","type":"page","link":"https:\/\/dbis.ibp.cz\/index.php\/research\/thrombolysis-in-relation-to-ischemic-stroke\/","title":{"rendered":"Thrombolysis in relation to ischemic stroke\u200b"},"content":{"rendered":"\t\t
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Thrombolysis in relation to ischemic stroke\u200b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Responsible person:<\/span> Jan V\u00edte\u010dek<\/span>
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Ischemic stroke is a disease with very high socioeconomic burden worldwide due to high incidence, mortality and morbidity. Ischemic stroke is caused by an occlusion of one or multiple cerebral arteries with a blood clot. Treatment priority in acute ischemic stroke is recanalization of such occluded artery. Currently, intravenous thrombolysis with a recombinant tissue plasminogen activator (rt-PA, alternatively known as alteplase) and\/or endovascular therapy (mechanical thrombectomy) are the only clinically approved treatment options. Of those, who receive rt-PA, more than a half fail to respond to the drug. The factors behind limited efficacy of rt-PA are still poorly understood a complicate novel thrombolytic drug design.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The essential workflow in the thrombolysis assays.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Therefore, we focus on the\u00a0in vitro\u00a0<\/em>modeling of events critical to vessel occlusion formation and thrombolysis or recanalization with a special emphasis of novel thrombolytic drug development. We have joined the extensive cooperation network covered by\u00a0Stroke Brno<\/span><\/b><\/a>\u00a0research cluster, where multiple partners bring an extensive expertise and interdiciplinarity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Thrombolysis in relation to ischemic stroke\u200b Responsible person: Jan V\u00edte\u010dek Ischemic stroke is a disease with very high socioeconomic burden worldwide due to high incidence, mortality and morbidity. Ischemic stroke is caused by an occlusion of one or multiple cerebral arteries with a blood clot. Treatment priority in acute ischemic stroke is recanalization of such occluded […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":33,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-1919","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/pages\/1919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/comments?post=1919"}],"version-history":[{"count":22,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/pages\/1919\/revisions"}],"predecessor-version":[{"id":3542,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/pages\/1919\/revisions\/3542"}],"up":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/pages\/33"}],"wp:attachment":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/media?parent=1919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}