{"id":2597,"date":"2024-06-26T23:49:10","date_gmt":"2024-06-26T21:49:10","guid":{"rendered":"https:\/\/dbis.ibp.cz\/?p=2597"},"modified":"2024-06-27T23:44:12","modified_gmt":"2024-06-27T21:44:12","slug":"new-publication-factors-influencing-the-efficacy-of-recombinant-tissue-plasminogen-activator-implications-for-ischemic-stroke-treatment","status":"publish","type":"post","link":"https:\/\/dbis.ibp.cz\/index.php\/2024\/06\/26\/new-publication-factors-influencing-the-efficacy-of-recombinant-tissue-plasminogen-activator-implications-for-ischemic-stroke-treatment\/","title":{"rendered":"New publication: Factors influencing the efficacy of recombinant tissue plasminogen activator: Implications for ischemic stroke treatment"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2597\" class=\"elementor elementor-2597\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-707fd47 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"707fd47\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-090949f\" data-id=\"090949f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c30c5e9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c30c5e9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-a0765ad\" data-id=\"a0765ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d435ad6 elementor-widget elementor-widget-heading\" data-id=\"d435ad6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">New publication: Factors influencing the efficacy of recombinant tissue plasminogen activator: Implications for ischemic stroke treatment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bffee39 elementor-widget elementor-widget-text-editor\" data-id=\"bffee39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr. Jan V\u00edte\u010dek&#8217;s group, based in our department, has published a new paper focused on ischemic stroke. The publication was produced in collaboration with Professor Robert Mikul\u00edk&#8217;s team from St. Anne&#8217;s University Hospital in Brno.<\/p><p><span style=\"font-size: 18px;\">This publication investigates factors that limit the efficacy of intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) in treating acute ischemic stroke. The study aims to understand the impact of clot size, rt-PA concentration, clot age, and the combination of rt-PA with heparin on the thrombolysis process. Using an in vitro model with red blood cell-dominant clots from healthy donors, the study found that clots larger than 50 \u03bcl are challenging to degrade at a clinically relevant rt-PA concentration of 1.3 mg\/l. Changes in rt-PA concentration only slightly affected clot degradation, and heparin had no impact on rt-PA-induced thrombolysis. Younger clots were more susceptible to thrombolysis, suggesting that prompt rt-PA treatment after stroke onset could improve outcomes.<\/span><\/p><p>\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb091d2 elementor-button-success elementor-align-center elementor-widget elementor-widget-button\" data-id=\"fb091d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371%2Fjournal.pone.0302269&#038;fbclid=IwZXh0bgNhZW0CMTAAAR2vw7qgLSA4C_V12aUv0mX53luf18GJS4CZ-lziXvYdEa025qnT8XJko2A_aem_GFPEWeDnq5-lJuLWst6JqQ\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Full text of the article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-80b68b8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"80b68b8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-033c1ef\" data-id=\"033c1ef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d8cddab elementor-widget elementor-widget-image\" data-id=\"d8cddab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"347\" src=\"https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2024\/06\/plos_one_ischemic-768x347.png\" class=\"attachment-medium_large size-medium_large wp-image-2605\" alt=\"\" srcset=\"https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2024\/06\/plos_one_ischemic-768x347.png 768w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2024\/06\/plos_one_ischemic-300x135.png 300w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2024\/06\/plos_one_ischemic-1024x462.png 1024w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2024\/06\/plos_one_ischemic.png 1165w\" sizes=\"(max-width: 768px) 100vw, 768px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Example from the results<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>New publication: Factors influencing the efficacy of recombinant tissue plasminogen activator: Implications for ischemic stroke treatment Dr. Jan V\u00edte\u010dek&#8217;s group, based in our department, has published a new paper focused on ischemic stroke. The publication was produced in collaboration with Professor Robert Mikul\u00edk&#8217;s team from St. Anne&#8217;s University Hospital in Brno. This publication investigates factors [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":2610,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[127],"tags":[],"class_list":["post-2597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-publication","entry","has-media"],"_links":{"self":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/2597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/comments?post=2597"}],"version-history":[{"count":5,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/2597\/revisions"}],"predecessor-version":[{"id":2611,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/2597\/revisions\/2611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/media\/2610"}],"wp:attachment":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/media?parent=2597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/categories?post=2597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/tags?post=2597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}