{"id":3603,"date":"2026-02-10T23:20:15","date_gmt":"2026-02-10T22:20:15","guid":{"rendered":"https:\/\/dbis.ibp.cz\/?p=3603"},"modified":"2026-02-10T23:42:03","modified_gmt":"2026-02-10T22:42:03","slug":"new-publication-revisiting-hyaluronan-catabolism-in-bacteroides-pathway-conservation-overlooked-proteins-and-predictive-accuracy","status":"publish","type":"post","link":"https:\/\/dbis.ibp.cz\/index.php\/2026\/02\/10\/new-publication-revisiting-hyaluronan-catabolism-in-bacteroides-pathway-conservation-overlooked-proteins-and-predictive-accuracy\/","title":{"rendered":"New publication: Revisiting Hyaluronan Catabolism in\u00a0Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3603\" class=\"elementor elementor-3603\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-358512d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"358512d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7cbf8d6\" data-id=\"7cbf8d6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-bebdf31 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bebdf31\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-e96b15b\" data-id=\"e96b15b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6a854d7 elementor-widget elementor-widget-heading\" data-id=\"6a854d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">New publication: Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88ff538 elementor-widget elementor-widget-text-editor\" data-id=\"88ff538\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>New publication by Dr. Turkov\u00e1 and Dr. Ambro\u017eov\u00e1 team.<\/p><p>In their latest study investigates how gut bacteria break down hyaluronan (HA), a common host- and diet-derived glycan. By combining protein analysis, functional assays, and quantitative proteomics, we found that sequence-based predictions alone cannot reliably identify HA-degrading Bacteroides. Experimental validation confirmed HA degradation and revealed that both canonical and noncanonical proteins are induced in response to HA. These findings improve our understanding of gut microbial glycan utilization and highlight factors that could enhance predictions of microbial ecological function.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a06a6af elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a06a6af\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-df9d80e\" data-id=\"df9d80e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aee4d3c elementor-widget elementor-widget-image\" data-id=\"aee4d3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"361\" src=\"https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-1024x361.jpg\" class=\"attachment-large size-large wp-image-3607\" alt=\"\" srcset=\"https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-1024x361.jpg 1024w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-300x106.jpg 300w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-768x271.jpg 768w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-1536x541.jpg 1536w, https:\/\/dbis.ibp.cz\/wp-content\/uploads\/2026\/02\/GA_hyaluronan_gut-2048x721.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Graphical Abstract: Hyaluronan degradation in Bacteroides cannot be reliably predicted from canonical PL8\/GH88 enzymes alone. Experimental validation reveals coordinated induction of noncanonical accessory proteins (BT4410\/BT4411), highlighting pathway plasticity and context-dependent glycosaminoglycan utilization.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c5ca95 elementor-button-success elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6c5ca95\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.70227\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Full text of the article<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3d6f4b5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3d6f4b5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-63417ec\" data-id=\"63417ec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>New publication: Revisiting Hyaluronan Catabolism in Bacteroides: Pathway Conservation, Overlooked Proteins, and Predictive Accuracy New publication by Dr. Turkov\u00e1 and Dr. Ambro\u017eov\u00e1 team. In their latest study investigates how gut bacteria break down hyaluronan (HA), a common host- and diet-derived glycan. By combining protein analysis, functional assays, and quantitative proteomics, we found that sequence-based predictions [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3604,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[127],"tags":[],"class_list":["post-3603","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-publication","entry","has-media"],"_links":{"self":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/3603","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/comments?post=3603"}],"version-history":[{"count":11,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/3603\/revisions"}],"predecessor-version":[{"id":3648,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/posts\/3603\/revisions\/3648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/media\/3604"}],"wp:attachment":[{"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/media?parent=3603"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/categories?post=3603"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dbis.ibp.cz\/index.php\/wp-json\/wp\/v2\/tags?post=3603"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}