Our colleague Michaela Chorvátová completed her internship at the Czech Centre for Phenogenomics in Vestex and below is her summary.

The internship (30.9. – 11.10. in CCP in Vestec) was focused on the role of Fam83h and its interaction with CK1 in T cell development, focusing on how this interaction influences thymocyte differentiation. Research conducted at Masaryk University (Bryjalab), DBIS, IBP, ACSR (Kubalalab), and the Czech Centre for Phenogenomics (CCP, Jana Balounová group) demonstrated across various models that both CK1 inhibition and Fam83h deficiency result in changed myelopoiesis, smaller thymuses and impaired B and T cell lymphopoiesis . At CCP, Fam83h-deficient mice were generated, and we (me with Tonka) investigated how CK1 and Fam83h regulate lymphocyte production and sought to identify the cells, mechanisms, and biological processes underlying impaired T and B cell development in these models.